Lipid polymorphism and the functional roles of lipids in biological membranes.
نویسندگان
چکیده
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منابع مشابه
Physical properties and functional roles of lipids in membranes
Biological membranes contain an astonishing variety of lipids. As detailed throughout this book, generation of this diversity requires elaborate metabolic pathways. The lipid compounds representing the end products of these pathways must bestow significant evolutionary advantages to the cellular or multicellular systems in which they reside, implying particular functional roles for each compone...
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Lipids, which adopt nonbilayer phases, have fascinated researchers as to the functional roles of these components in biomembranes. In particular, lipids capable of adopting the hexagonal H(II) phase have received considerable attention because of the observation that such lipids can promote membrane fusion. In the rational design of lipid-based delivery systems, H(II) phase lipids have been emp...
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One of the fundamental problems in membrane biology is that of lipid diversity. The number of chemically different membrane lipids is much larger than other key biological building blocks such as nucleotides, amino acids, and carbohydrates. For instance, a relatively simple biomembrane such as that of the red blood cell contains well over a hundred different lipid species. Except for some metab...
متن کاملLipid polymorphism and the roles of lipids in membranes.
The reasons for lipid diversity in membranes are not understood. Here we review evidence supporting the proposal that factors related to the polymorphic capabilities of lipids provide a rationale for lipid diversity. In particular, the ability of lipids to adopt different polymorphic phases appears to be related to a generalized shape property, where lipids with a cylindrical geometry preferent...
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عنوان ژورنال:
- Biochimica et biophysica acta
دوره 559 4 شماره
صفحات -
تاریخ انتشار 1979